Nosocomial outbreak of SARS-CoV-2 infection in a haematological unit - High mortality rate in infected patients with haematologic malignancies.
Identifieur interne : 000401 ( Main/Exploration ); précédent : 000400; suivant : 000402Nosocomial outbreak of SARS-CoV-2 infection in a haematological unit - High mortality rate in infected patients with haematologic malignancies.
Auteurs : Monika M. Biernat [Pologne] ; Aleksander Zi Czuk [Pologne] ; Paweł Biernat [Pologne] ; Aleksandra Bogucka-Fedorczuk [Pologne] ; Jacek Kwiatkowski [Pologne] ; El Bieta Kalici Ska [Pologne] ; Dominik Marciniak [Pologne] ; Krzysztof Simon [Pologne] ; Tomasz Wr Bel [Pologne]Source :
- Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [ 1873-5967 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Betacoronavirus (MeSH), Co-infection (microbiologie), Co-infection (mortalité), Co-infection (virologie), Europe (épidémiologie), Facteurs de risque (MeSH), Facteurs temps (MeSH), Facteurs âges (MeSH), Femelle (MeSH), Humains (MeSH), Infection croisée (mortalité), Infection croisée (virologie), Infections à coronavirus (mortalité), Jeune adulte (MeSH), Mâle (MeSH), Pandémies (MeSH), Personnel de santé (statistiques et données numériques), Pneumopathie virale (mortalité), Sujet âgé (MeSH), Tumeurs hématologiques (complications), Études prospectives (MeSH).
- MESH :
- microbiologie : Co-infection.
- mortalité : Co-infection, Infection croisée, Infections à coronavirus, Pneumopathie virale.
- statistiques et données numériques : Personnel de santé.
- virologie : Co-infection, Infection croisée.
- épidémiologie : Europe, Tumeurs hématologiques.
- Adulte, Adulte d'âge moyen, Betacoronavirus, Facteurs de risque, Facteurs temps, Facteurs âges, Femelle, Humains, Jeune adulte, Mâle, Pandémies, Sujet âgé, Études prospectives.
English descriptors
- KwdEn :
- Adult (MeSH), Age Factors (MeSH), Aged (MeSH), Betacoronavirus (MeSH), Coinfection (microbiology), Coinfection (mortality), Coinfection (virology), Coronavirus Infections (mortality), Cross Infection (mortality), Cross Infection (virology), Europe (epidemiology), Female (MeSH), Health Personnel (statistics & numerical data), Hematologic Neoplasms (complications), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (mortality), Prospective Studies (MeSH), Risk Factors (MeSH), Time Factors (MeSH), Young Adult (MeSH).
- MESH :
- geographic , epidemiology : Europe.
- complications : Hematologic Neoplasms.
- microbiology : Coinfection.
- mortality : Coinfection, Coronavirus Infections, Cross Infection, Pneumonia, Viral.
- statistics & numerical data : Health Personnel.
- virology : Coinfection, Cross Infection.
- Adult, Age Factors, Aged, Betacoronavirus, Female, Humans, Male, Middle Aged, Pandemics, Prospective Studies, Risk Factors, Time Factors, Young Adult.
Abstract
BACKGROUND
Here we report nosocomial outbreak of COVID-19 among patients in a haematological unit. To our knowledge this is the first report from Central Europe comparing morbidity and mortality in infected and non-infected patients after exposure to SARS-CoV-2.
METHODS
The outbreak involved 39 individuals: 19 patients and 20 health care workers. The SARS-CoV-2 test by nasopharyngeal swabs was performed by real-time RT-PCR. Exposed patients were divided into two groups: quarantine patients with and without COVID-19. All patients were prospectively examined at the following time points: 0, 7 days, 14 days, 21 days and 28 days after confirmation or exclusion of SARS-CoV-2.
RESULTS
Infection was confirmed in a total of 5/20 health care workers and 10/19 patients. Among the patients positive for SARS-CoV-2 infection, the mortality rate was 36.8 %. The probability of death in patients infected with SARS-CoV-2 increased 8-fold (p = 0.03). Bacterial, fungal, and viral co-infection significantly decreased survival in these patients (p < 0.05). Additionally, the probability of death was much higher in patients older than 40 years of age (p = 0.032).
CONCLUSION
This study showed significantly higher mortality rate in COVID-19 patients with haematologic diseases compared to the non-infected patient group. Haematologic patients with COVID-19 have 50 % less chance of survival.
DOI: 10.1016/j.jcv.2020.104574
PubMed: 32769026
PubMed Central: PMC7395815
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Electronic address: j.k.kwiatkowski@wp.pl.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367, Wroclaw</wicri:regionArea><wicri:noRegion>Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Kalici Ska, El Bieta" sort="Kalici Ska, El Bieta" uniqKey="Kalici Ska E" first="El Bieta" last="Kalici Ska">El Bieta Kalici Ska</name><affiliation wicri:level="1"><nlm:affiliation>Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367, Wroclaw, Poland. Electronic address: elzbieta.kalicinska@umed.wroc.pl.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367, Wroclaw</wicri:regionArea><wicri:noRegion>Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Marciniak, Dominik" sort="Marciniak, Dominik" uniqKey="Marciniak D" first="Dominik" last="Marciniak">Dominik Marciniak</name><affiliation wicri:level="1"><nlm:affiliation>Department of Drugs Form Technology, Wroclaw Medical University, Borowska Street 211A, 50-556, Wroclaw, Poland. Electronic address: dominik.marciniak@umed.wroc.pl.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Drugs Form Technology, Wroclaw Medical University, Borowska Street 211A, 50-556, Wroclaw</wicri:regionArea><wicri:noRegion>Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Simon, Krzysztof" sort="Simon, Krzysztof" uniqKey="Simon K" first="Krzysztof" last="Simon">Krzysztof Simon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases and Hepatology, Wroclaw Medical University, Koszarowa Street 5, 51-149, Wroclaw, Poland. Electronic address: krzysztof.simon@umed.wroc.pl.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Infectious Diseases and Hepatology, Wroclaw Medical University, Koszarowa Street 5, 51-149, Wroclaw</wicri:regionArea><wicri:noRegion>Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Wr Bel, Tomasz" sort="Wr Bel, Tomasz" uniqKey="Wr Bel T" first="Tomasz" last="Wr Bel">Tomasz Wr Bel</name><affiliation wicri:level="1"><nlm:affiliation>Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367, Poland. Electronic address: tomasz.wrobel@umed.wroc.pl.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367</wicri:regionArea><wicri:noRegion>50-367</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32769026</idno><idno type="pmid">32769026</idno><idno type="doi">10.1016/j.jcv.2020.104574</idno><idno type="pmc">PMC7395815</idno><idno type="wicri:Area/Main/Corpus">000748</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000748</idno><idno type="wicri:Area/Main/Curation">000748</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000748</idno><idno type="wicri:Area/Main/Exploration">000748</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Nosocomial outbreak of SARS-CoV-2 infection in a haematological unit - High mortality rate in infected patients with haematologic malignancies.</title><author><name sortKey="Biernat, Monika M" sort="Biernat, Monika M" uniqKey="Biernat M" first="Monika M" last="Biernat">Monika M. Biernat</name><affiliation wicri:level="1"><nlm:affiliation>Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367, Wroclaw, Poland. Electronic address: monika.biernat@umed.wroc.pl.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367, Wroclaw</wicri:regionArea><wicri:noRegion>Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Zi Czuk, Aleksander" sort="Zi Czuk, Aleksander" uniqKey="Zi Czuk A" first="Aleksander" last="Zi Czuk">Aleksander Zi Czuk</name><affiliation wicri:level="1"><nlm:affiliation>Department of Forensic Medicine, Wroclaw Medical University, Infectious Diseases Unit, Gromkowski Regional Hospital in Wrocław, Mikulicz-Radecki Street 4, Koszarowa Street 5, 51-149 50-345, Wroclaw, Poland. Electronic address: alek.zinczuk@gmail.com.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Forensic Medicine, Wroclaw Medical University, Infectious Diseases Unit, Gromkowski Regional Hospital in Wrocław, Mikulicz-Radecki Street 4, Koszarowa Street 5, 51-149 50-345, Wroclaw</wicri:regionArea><wicri:noRegion>Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Biernat, Pawel" sort="Biernat, Pawel" uniqKey="Biernat P" first="Paweł" last="Biernat">Paweł Biernat</name><affiliation wicri:level="1"><nlm:affiliation>Department of Drugs Form Technology, Wroclaw Medical University, Borowska Street 211A, 50-556, Wroclaw, Poland. Electronic address: pawel.biernat@umed.wroc.pl.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Drugs Form Technology, Wroclaw Medical University, Borowska Street 211A, 50-556, Wroclaw</wicri:regionArea><wicri:noRegion>Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Bogucka Fedorczuk, Aleksandra" sort="Bogucka Fedorczuk, Aleksandra" uniqKey="Bogucka Fedorczuk A" first="Aleksandra" last="Bogucka-Fedorczuk">Aleksandra Bogucka-Fedorczuk</name><affiliation wicri:level="1"><nlm:affiliation>Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367, Wroclaw, Poland. Electronic address: aleksandra.bogucka-fedorczuk@umed.wroc.pl.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367, Wroclaw</wicri:regionArea><wicri:noRegion>Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Kwiatkowski, Jacek" sort="Kwiatkowski, Jacek" uniqKey="Kwiatkowski J" first="Jacek" last="Kwiatkowski">Jacek Kwiatkowski</name><affiliation wicri:level="1"><nlm:affiliation>Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367, Wroclaw, Poland. Electronic address: j.k.kwiatkowski@wp.pl.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367, Wroclaw</wicri:regionArea><wicri:noRegion>Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Kalici Ska, El Bieta" sort="Kalici Ska, El Bieta" uniqKey="Kalici Ska E" first="El Bieta" last="Kalici Ska">El Bieta Kalici Ska</name><affiliation wicri:level="1"><nlm:affiliation>Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367, Wroclaw, Poland. Electronic address: elzbieta.kalicinska@umed.wroc.pl.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367, Wroclaw</wicri:regionArea><wicri:noRegion>Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Marciniak, Dominik" sort="Marciniak, Dominik" uniqKey="Marciniak D" first="Dominik" last="Marciniak">Dominik Marciniak</name><affiliation wicri:level="1"><nlm:affiliation>Department of Drugs Form Technology, Wroclaw Medical University, Borowska Street 211A, 50-556, Wroclaw, Poland. Electronic address: dominik.marciniak@umed.wroc.pl.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Drugs Form Technology, Wroclaw Medical University, Borowska Street 211A, 50-556, Wroclaw</wicri:regionArea><wicri:noRegion>Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Simon, Krzysztof" sort="Simon, Krzysztof" uniqKey="Simon K" first="Krzysztof" last="Simon">Krzysztof Simon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases and Hepatology, Wroclaw Medical University, Koszarowa Street 5, 51-149, Wroclaw, Poland. Electronic address: krzysztof.simon@umed.wroc.pl.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Infectious Diseases and Hepatology, Wroclaw Medical University, Koszarowa Street 5, 51-149, Wroclaw</wicri:regionArea><wicri:noRegion>Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Wr Bel, Tomasz" sort="Wr Bel, Tomasz" uniqKey="Wr Bel T" first="Tomasz" last="Wr Bel">Tomasz Wr Bel</name><affiliation wicri:level="1"><nlm:affiliation>Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367, Poland. Electronic address: tomasz.wrobel@umed.wroc.pl.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367</wicri:regionArea><wicri:noRegion>50-367</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</title><idno type="eISSN">1873-5967</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Age Factors (MeSH)</term><term>Aged (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Coinfection (microbiology)</term><term>Coinfection (mortality)</term><term>Coinfection (virology)</term><term>Coronavirus Infections (mortality)</term><term>Cross Infection (mortality)</term><term>Cross Infection (virology)</term><term>Europe (epidemiology)</term><term>Female (MeSH)</term><term>Health Personnel (statistics & numerical data)</term><term>Hematologic Neoplasms (complications)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (mortality)</term><term>Prospective Studies (MeSH)</term><term>Risk Factors (MeSH)</term><term>Time Factors (MeSH)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Co-infection (microbiologie)</term><term>Co-infection (mortalité)</term><term>Co-infection (virologie)</term><term>Europe (épidémiologie)</term><term>Facteurs de risque (MeSH)</term><term>Facteurs temps (MeSH)</term><term>Facteurs âges (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Infection croisée (mortalité)</term><term>Infection croisée (virologie)</term><term>Infections à coronavirus (mortalité)</term><term>Jeune adulte (MeSH)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Personnel de santé (statistiques et données numériques)</term><term>Pneumopathie virale (mortalité)</term><term>Sujet âgé (MeSH)</term><term>Tumeurs hématologiques (complications)</term><term>Études prospectives (MeSH)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Europe</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hematologic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Co-infection</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Coinfection</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coinfection</term><term>Coronavirus Infections</term><term>Cross Infection</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Co-infection</term><term>Infection croisée</term><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Health Personnel</term></keywords><keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Personnel de santé</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Co-infection</term><term>Infection croisée</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coinfection</term><term>Cross Infection</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Europe</term><term>Tumeurs hématologiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Betacoronavirus</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Prospective Studies</term><term>Risk Factors</term><term>Time Factors</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Betacoronavirus</term><term>Facteurs de risque</term><term>Facteurs temps</term><term>Facteurs âges</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Pandémies</term><term>Sujet âgé</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Here we report nosocomial outbreak of COVID-19 among patients in a haematological unit. To our knowledge this is the first report from Central Europe comparing morbidity and mortality in infected and non-infected patients after exposure to SARS-CoV-2.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>The outbreak involved 39 individuals: 19 patients and 20 health care workers. The SARS-CoV-2 test by nasopharyngeal swabs was performed by real-time RT-PCR. Exposed patients were divided into two groups: quarantine patients with and without COVID-19. All patients were prospectively examined at the following time points: 0, 7 days, 14 days, 21 days and 28 days after confirmation or exclusion of SARS-CoV-2.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Infection was confirmed in a total of 5/20 health care workers and 10/19 patients. Among the patients positive for SARS-CoV-2 infection, the mortality rate was 36.8 %. The probability of death in patients infected with SARS-CoV-2 increased 8-fold (p = 0.03). Bacterial, fungal, and viral co-infection significantly decreased survival in these patients (p < 0.05). Additionally, the probability of death was much higher in patients older than 40 years of age (p = 0.032).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>This study showed significantly higher mortality rate in COVID-19 patients with haematologic diseases compared to the non-infected patient group. Haematologic patients with COVID-19 have 50 % less chance of survival.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32769026</PMID><DateCompleted><Year>2020</Year><Month>10</Month><Day>05</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>05</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-5967</ISSN><JournalIssue CitedMedium="Internet"><Volume>130</Volume><PubDate><Year>2020</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</Title><ISOAbbreviation>J Clin Virol</ISOAbbreviation></Journal><ArticleTitle>Nosocomial outbreak of SARS-CoV-2 infection in a haematological unit - High mortality rate in infected patients with haematologic malignancies.</ArticleTitle><Pagination><MedlinePgn>104574</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1386-6532(20)30316-4</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jcv.2020.104574</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Here we report nosocomial outbreak of COVID-19 among patients in a haematological unit. To our knowledge this is the first report from Central Europe comparing morbidity and mortality in infected and non-infected patients after exposure to SARS-CoV-2.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The outbreak involved 39 individuals: 19 patients and 20 health care workers. The SARS-CoV-2 test by nasopharyngeal swabs was performed by real-time RT-PCR. Exposed patients were divided into two groups: quarantine patients with and without COVID-19. All patients were prospectively examined at the following time points: 0, 7 days, 14 days, 21 days and 28 days after confirmation or exclusion of SARS-CoV-2.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Infection was confirmed in a total of 5/20 health care workers and 10/19 patients. Among the patients positive for SARS-CoV-2 infection, the mortality rate was 36.8 %. The probability of death in patients infected with SARS-CoV-2 increased 8-fold (p = 0.03). Bacterial, fungal, and viral co-infection significantly decreased survival in these patients (p < 0.05). Additionally, the probability of death was much higher in patients older than 40 years of age (p = 0.032).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">This study showed significantly higher mortality rate in COVID-19 patients with haematologic diseases compared to the non-infected patient group. Haematologic patients with COVID-19 have 50 % less chance of survival.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Biernat</LastName><ForeName>Monika M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367, Wroclaw, Poland. Electronic address: monika.biernat@umed.wroc.pl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zińczuk</LastName><ForeName>Aleksander</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Forensic Medicine, Wroclaw Medical University, Infectious Diseases Unit, Gromkowski Regional Hospital in Wrocław, Mikulicz-Radecki Street 4, Koszarowa Street 5, 51-149 50-345, Wroclaw, Poland. Electronic address: alek.zinczuk@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Biernat</LastName><ForeName>Paweł</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Drugs Form Technology, Wroclaw Medical University, Borowska Street 211A, 50-556, Wroclaw, Poland. Electronic address: pawel.biernat@umed.wroc.pl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bogucka-Fedorczuk</LastName><ForeName>Aleksandra</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367, Wroclaw, Poland. Electronic address: aleksandra.bogucka-fedorczuk@umed.wroc.pl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kwiatkowski</LastName><ForeName>Jacek</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367, Wroclaw, Poland. Electronic address: j.k.kwiatkowski@wp.pl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kalicińska</LastName><ForeName>Elżbieta</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367, Wroclaw, Poland. Electronic address: elzbieta.kalicinska@umed.wroc.pl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marciniak</LastName><ForeName>Dominik</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Drugs Form Technology, Wroclaw Medical University, Borowska Street 211A, 50-556, Wroclaw, Poland. Electronic address: dominik.marciniak@umed.wroc.pl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simon</LastName><ForeName>Krzysztof</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases and Hepatology, Wroclaw Medical University, Koszarowa Street 5, 51-149, Wroclaw, Poland. Electronic address: krzysztof.simon@umed.wroc.pl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wróbel</LastName><ForeName>Tomasz</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367, Poland. Electronic address: tomasz.wrobel@umed.wroc.pl.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Clin Virol</MedlineTA><NlmUniqueID>9815671</NlmUniqueID><ISSNLinking>1386-6532</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D060085" MajorTopicYN="N">Coinfection</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003428" MajorTopicYN="N">Cross Infection</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005060" MajorTopicYN="N" Type="Geographic">Europe</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006282" MajorTopicYN="N">Health Personnel</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019337" MajorTopicYN="N">Hematologic Neoplasms</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Haematological malignancies</Keyword><Keyword MajorTopicYN="N">Hospital-acquired infection</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>07</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>10</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32769026</ArticleId><ArticleId IdType="pii">S1386-6532(20)30316-4</ArticleId><ArticleId IdType="doi">10.1016/j.jcv.2020.104574</ArticleId><ArticleId IdType="pmc">PMC7395815</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Pologne</li></country></list><tree><country name="Pologne"><noRegion><name sortKey="Biernat, Monika M" sort="Biernat, Monika M" uniqKey="Biernat M" first="Monika M" last="Biernat">Monika M. Biernat</name></noRegion><name sortKey="Biernat, Pawel" sort="Biernat, Pawel" uniqKey="Biernat P" first="Paweł" last="Biernat">Paweł Biernat</name><name sortKey="Bogucka Fedorczuk, Aleksandra" sort="Bogucka Fedorczuk, Aleksandra" uniqKey="Bogucka Fedorczuk A" first="Aleksandra" last="Bogucka-Fedorczuk">Aleksandra Bogucka-Fedorczuk</name><name sortKey="Kalici Ska, El Bieta" sort="Kalici Ska, El Bieta" uniqKey="Kalici Ska E" first="El Bieta" last="Kalici Ska">El Bieta Kalici Ska</name><name sortKey="Kwiatkowski, Jacek" sort="Kwiatkowski, Jacek" uniqKey="Kwiatkowski J" first="Jacek" last="Kwiatkowski">Jacek Kwiatkowski</name><name sortKey="Marciniak, Dominik" sort="Marciniak, Dominik" uniqKey="Marciniak D" first="Dominik" last="Marciniak">Dominik Marciniak</name><name sortKey="Simon, Krzysztof" sort="Simon, Krzysztof" uniqKey="Simon K" first="Krzysztof" last="Simon">Krzysztof Simon</name><name sortKey="Wr Bel, Tomasz" sort="Wr Bel, Tomasz" uniqKey="Wr Bel T" first="Tomasz" last="Wr Bel">Tomasz Wr Bel</name><name sortKey="Zi Czuk, Aleksander" sort="Zi Czuk, Aleksander" uniqKey="Zi Czuk A" first="Aleksander" last="Zi Czuk">Aleksander Zi Czuk</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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